HOBt·H2O CAS 123333-53-9 1-Hydroxybenzotriazole Hydrate Peptide Coupling Reagent Purity >99.0% (HPLC) Factory

Short Description:

1-Hydroxybenzotriazole Hydrate

Synonyms: HOBt·H2O; HOBt Hydrate

CAS: 123333-53-9

Related CAS: 80029-43-2

Purity: >99.0% (HPLC)

Appearance: White Crystalline Powder

Peptide Coupling Reagents, High Quality

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 1-Hydroxybenzotriazole Hydrate (HOBt·H2O) (CAS: 123333-53-9; 80029-43-2) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase HOBt·H2O, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	1-Hydroxybenzotriazole Hydrate
Synonyms	HOBt·H2O; HOBt Hydrate; HOBTM; 1-Hydroxybenzotriazole Monohydrate; 1-Hydroxy-1H-Benzotriazole Hydrate; 1-Oxy-Benztriazol Hydrate
Stock Status	In Stock, Commercial Scale
CAS Number	123333-53-9
Related CAS	80029-43-2
Molecular Formula	C6H5N3O·H2O
Molecular Weight	153.15 g/mol; 135.1 (Anhydrous Basis)
Melting Point	156.0~160.0℃
Density	1.065 g/cm3
Sensitive	Light Sensitive
Solubility in Methanol	Soluble in Methanol, Almost Transparency
Storage Temp.	Cool & Dry Place (≤4℃)
COA & MSDS	Available
Category	Coupling Reagents
Brand	Ruifu Chemical

Specifications:

Items	Inspection Standards	Results
Appearance	White Crystalline Powder	Complies
Melting Point	156.0~160.0℃	157.4~158.6℃
Water by Karl Fischer	11.0~13.0%	12.1%
Residue on Ignition	<0.20%	0.1%
Heavy Metals (Pb)	≤20ppm	<20ppm
Purity / Analysis Method	>99.0% (HPLC)	99.90%
300 MHz 1HNMR Spectrum	Consistent with Structure	Complies
Infrared Spectrum	Consistent with Structure	Complies
Conclusion	The product has been tested & complies with the given specifications

Package/Storage/Shipping:

Package: Bottle, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry (≤4℃) warehouse away from incompatible substances. Protect from light and moisture.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

123333-53-9 - Risk and Safety:

Hazard Symbols F - Flammable
Risk Codes
R5 - Heating may cause an explosion
R11 - Highly Flammable
R44 - Risk of explosion if heated under confinement
R1 - Explosive when dry
Safety Description
S15 - Keep away from heat.
S16 - Keep away from sources of ignition.
S35 - This material and its container must be disposed of in a safe way.
S7/9 -
S33 - Take precautionary measures against static discharges.
S60 - This material and its container must be disposed of as hazardous waste.
S37 - Wear suitable gloves.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs UN 3380 4.1/PG 1
WGK Germany -
FLUKA BRAND F CODES 4.10-8
HS Code 2933990099
Hazard Note Highly Flammable

Application:

1-Hydroxybenzotriazole Hydrate (HOBt·H2O) (CAS: 123333-53-9; 80029-43-2), additive for oligonucleotide couplings and in racemization-free peptide couplings.
HOBt·H2O is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.
Synthesis of Ubenimex intermediates and polypeptide protectants. It is widely used in the condensation reaction of polypeptides with carbodiimide condensers, which can significantly reduce the racemization ratio, and is also used to prevent the production of racemization during the condensation of polypeptide fragments.
HOBt is one of the most effective suppressors of racemization in carbodiimide-mediated reactions. The most important drawback of the additive lies in its explosive character, especially in water-free form. Therefore, its availability is more restricted today but it can be substituted by more stable additives as OxymaPure and K-Oxyma. Polymer-bound HOBt is used for the formation of medium ring lactams with DCC in the presence of resin-bound esters and also for amides synthesis.