Losartan Potassium CAS 124750-99-8 API Factory Antihypertensive High Purity

Short Description:

Chemical Name: Losartan Potassium 

CAS: 124750-99-8

Appearance: White or Almost White Crystalline Powder

Angiotensin II Receptor Antagonist Antihypertensive 

API High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com


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Description:

Supply Losartan Potassium and Related Intermediates with High Quality
Losartan Potassium CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9

Chemical Properties:

Chemical Name Losartan Potassium
Synonyms DuP 753; Cozaar; 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Salt
CAS Number 124750-99-8
CAT Number RF-API98
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C22H22ClKN6O
Molecular Weight 461.01  
Melting Point  263.0~265.0℃
Solubility Freely Soluble in Water and in Methanol, Slightly Soluble in Acetonitrile.
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White or Almost White Crystalline Powder
Identification A Infrared Absorption: Must Similar to Reference Standard
Identification B Ultraviolet absorption: Must Similar to Reference Standard
Test for Potassium Must be Positive
Water Content (K.F) ≤0.50%
Heavy Metals ≤10ppm
Related Substances (HPLC)
Any Individual Impurity ≤0.20%
Total Impurities ≤0.50%
Residual Solvents (GC)
Cyclohexane ≤0.10%
Isopropyl Alcohol ≤0.20%
Assay/Analysis Method 98.5~101.0% (HPLC, calculated on anhydrous, solvent-free basis)
N-Nitrosodiethylamine  ≤0.177ppm (NDEA)
N-Nitrosodimethylamine  ≤0.640ppm (NDMS)
Particle Size 90% Less Than 38 Microns
Shelf Life 24 Months
Test Standard Enterprise Standard
Usage API, Angiotensin II Receptor Antagonist Antihypertensive

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

1

FAQ:

Application:

Losartan Potassium is the first potent and selective non-peptide angiotensin II receptor type 1 (AT1) antagonist introduced to the market as a once-daily oral antihypertensive. The concentration that inhibits 50% of the binding of angiotensin II (IC50) is 20 nM. Losartan (40 μM) affects ISC but prevents the effect of ANGII on ISC. Losartan significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells. The combination of losartan and anti-miR-155 has a significantly greater antiproliferative effect compared to each drug alone. It is metabolized to produce the 5-carboxylic acid metabolite (EXP3174) and is reported to lower blood pressure. It is currently being researched as a potential treatment for COVID-19 for its potential to mitigate or possibly attenuate the symptoms of COVID-19.
1. For the treatment of essential hypertension, it can be used alone or in combination with other antihypertensive drugs (such as diuretics). 2. For the treatment of heart failure, it can be used alone or in combination with cardiotonic or diuretic Chemicalbook drugs. 3. Preventing stroke in patients with hypertension and left ventricular hypertrophy. 4. It is used to slow the progression of nephropathy in patients with type 2 diabetes associated with nephropathy and hypertension.

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